On "big nights out" (about once a month) friends of mine "plug" ecstasy tablets — by which I mean they each stick one up their butt instead of swallowing.

They claim that is a "safer" way to ingest E because it bypasses the liver and goes right into the bloodstream. They also claim the effects are heightened.

I have been tempted to try this method as they swear by it, but thought I'd get your opinion first — are there any potential side effects to plugging? Is it really a "safer" way to use E?

Is lsd safe to use while on an SSRI.

What are the effects of sniffing lighter fluid? I recently had a friend sit in a car to listen to music and smell lighter fluid. He tells me he gets a high from this. What are the effects of doing this? I would appreciate this to educate my friend.

I am a 32-year-old woman dating a very nice man my age. My boyfriend and I have been dating for just about a year and we are serious about each other. He has severe asthma and has to be on high doses of steroids during and for a long time after a flare-up. The problem is these steroids have a terrible effect on him: he breaks out in acne; he is irritable and loses control of his temper; his appetite is voracious; he puffs out in his stomach and face.

The problem with his temper and irritability is what most bothers me, it is as if he has a completely different personality and sometimes it is frightening. We have talked to his doctor who says that these steroids are the drug of choice and if he does not take them as an outpatient, he would have to be hospitalized and put on the same medications.

As I said, his personality can be frightening on the steroids, but I have seen my boyfriend in an asthma attack which is even more frightening. I once talked to a therapist about this problem. Maybe I should have been more careful in choosing a therapist, but this woman came from a feminist perspective and in a sense told me that I should break up with this man. I don't think that this is the solution since I love him very much and I know that off steroids he is the man I love.

Could you possibly tell me the interactive effects of Zoloft (the anti-depressant) and MDMA (Ecstasy)?

1) I am wondering about the direct effects nitrous oxide has on the brain, and if it is a fallacy that it kills brain cells.

2) What are the health dangers of inhaling nitrous oxide? I have heard people say that it "kills brain cells," but no one seems to know how, to what extent, and what the resulting effects are. Since nitrous oxide is commonly administered as anesthesia, is there a safe way to consume it for recreational use? If the user controls her oxygen intake, do the harmful effects (if any) still occur?

I have a friend at school who quit smoking last year in January, and went back to it in October. I have no idea why, and he also started doing other drugs, such as smoking blunts, doing ecstasy, and taking steroids. The drug that I am worried about him doing the most is ecstasy, because it's a dangerous drug. Also, he is always talking about doing drugs. How can I help him? I still want him to be my friend. Please help. This is serious.

Lately, I have been doing a drug called Special K. I know it is a sedative/tranquilizer (what's the difference?), but very little about side effects, etc. Also, can you go over similar information about the drug X?

I am a teenage girl currently taking Adderall (20 mg) to treat my ADHD. My question: does taking this medication affect sexual wantings or behavior? I am supposed to start taking it at 7:00am so it will wear out at about 9:00 or 9:30pm. Since I go out later at night, my medicine is usually worn off before I engage in any kind of sexual activity. But sometimes on weekends I wake up late and have to take it at later times such as 12:00 or 1:00pm. Since then it will not wear off until after I go out, would being on Adderall affect my sexual behavior? I feel like I am less "horny" when on Adderall and sex is worse because of the lack of my desires. Does this have anything to do with my medicine or is it just a coincidence?